South Carolina is a state in the Southeastern region of the United States. South Carolina was named in honor of King Charles I of England, who first formed the English colony, with Carolus being Latin for "Charles". South Carolina became the eighth state to ratify the U.S. Constitution on May 23, 1788. It also became the first state to vote in favor of secession from the Union on December 20, 1860. After the American Civil War, it was readmitted into the United States on June 25, 1868.
There is evidence of human activity in the area dating to about 40,000 years ago. At the time Europeans arrived, marking the end of the Pre-Columbian era around 1600, there were many separate Native American tribes, the largest being the Cherokee and the Catawba, with the total population being up to 20,000.